Designs for Health®

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30 Blister Pack Price: $38.00

Code: SAM030




SAMe30 Blister Pack

SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate. SAMe is the most active of all methyl donors and has been compared to ATP in its importance for the body.

SAMe is involved in the synthesis of:

  • Neurotransmitters

  • The hormone melatonin

  • Phospholipids

  • Polyamines, which control cellular growth

It is also the source of methyl groups inside the nucleus for DNA methylation which controls gene expression and masking of genetic damage.

Size: 30 tablets Each tablet contains:

  • Vitamin B6 (Pyridoxine HCL) 2 mg

  • Folic Acid 200 mcg

  • Vitamin B12(Cyanocobalamin) 50 mcg

  • S-Adenosyl L-Methionine (as Disulfate Monotosylate) 200 mg

Other Ingredients: Microcrystalline cellulose, croscarmellose sodium, methacrylic acid co-polymer, colloidal silicon dioxide, magnesium stearate, triethyl citrate, stearic acid, citric acid, ascorbic acid, riboflavin.

SAMe is extremely sensitive to degradation from air and moisture. Designs for Health SAMe is superior to other products on the market due to its stability in the nitrogen blister packs and maximized bioavailability by an enteric coating. It is recommended that each blister be opened immediately before ingesting the tablet. Designs for Health SAMe tablets are enterically coated in order to prevent its breakdown by stomach acidity and promote intact absorption in the small intestine. Vitamins B6, B12, and folate were added in order to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine.

Even if the body is producing normal or average levels of SAMe, certain physiological states create an increased demand for it, such as: aging, dietary deficiency, inflammatory states, emotional/physical stress or genetic polymorphysms. Sub-optimal levels of SAMe in some individuals may be due to insufficient amounts of the precursor amino acid methionine (vegetarianism or poor protein intake). Age related decline in enzyme difficiencies throughout the body can be improved by increasing the supply of enzyme cofactors such as SAMe, B-vitamins, and magnesium.

Initial dosing of SAMe should begin at 200 mg early in the day. SAMe should not be taken in the evening, because its natural circadian rhythm is high during the day and low in the evening and throughout the night. The dose can be increased after 5 days or more, 200mg at a time, while evaluating its effectiveness. Absorption of SAMe is optimal on an empty stomach, however, taking SAMe with meals may be more clinically efficacious by slowing its delivery into the blood stream and creating a more natural increase in SAMe concentrations similar to that of endogenous production.

Recommended Use
As a dietary supplement, take one tablet one to two times daily, preferably on an empty stomach, or as directed by your health care practitioner.

WARNING; Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.

This product does not contain wheat, soy, corn, yeast, milk, or gluten.



These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Medical Disclaimer: The information on this web site is for general informational purposes only. It is not a substitute for a medical evaluation. If you feel that medical interventions are necessary, please check with your physician and Dietary Supplements.