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Summary of Terms

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>>Brava's "Bredesen Protocol" Pg. 1 Introtroducion

>> Brava's "Bredesen Protocol" Pg. 2 Terminology


Brava's "Bredesen Protocol" Pg. 3 The Science


Brava's "Bredesen Protocol" Pg. 4 Bredesen Cognoscopy


Brava's "Bredesen Protocol" Pg. 5 Nutrition & Herbs Support Protection


Brava "Bredesen Protocol" Pg. 6 Protect Your Brain Life Style

Brava "Bredesen Protocol" Pg. 7 Cognitive Testing

Brava "Bredesen Protocol" Pg 8 Summary


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Alzheimer’s Disease (AD): A degenerative progressive brain disease that impairs memory, language, thought, judgment and behavior. It is not just “old age,” it can strike in the forties and fifties.  It is the most common disorder responsible for 60%-70% of neuro-degenerative diseases. Alzheimer’s  starts in late middle age or in old age, that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood, and that is marked histologically by the degeneration of brain.
Complementary, Alternative, and Integrative Medicine & Health
A neuro-degenerative disease that is responsible for the greatest burden of brain conditions where cognitive or memory impairment is severe enough to affect daily life, but it does not identify the underlying cause.  Thus, not all dementia is Alzheimer’s disease. There are many causes of dementia, including Vascular Dementia, Frontotemporal Dementia, Lewy Body dementia, and others, including pre-Alzheimer's disease (SCI and MCI described below).

The National Center for Complementary and Integrative Health (NCCIH) is a sub-division of National Institutes of Health (NIH), the Federal Government's lead agency for scientific research.
Neuro-degenerative Disease:
Neurodegenerative disease is an umbrella term for a range of conditions that primarily affect the neurons in the human brain. Neurons are the building blocks of the nervous system which includes the brain and spinal cord. Neurons normally don’t reproduce or replace themselves (See Neurogenisis and Neuroplasticity below) so when they become damaged or die they cannot be replaced by the body. Examples of neurodegenerative diseases include Parkinson’s, Alzheimer’s, and Huntington’s disease. Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and / or death of nerve cells. This causes problems with movement (called ataxias), or mental functioning (called dementias).
NIH-Neuro-degenerative Research:
The Neuro-degenerative cluster portfolio consists of research on adult onset neurodegenerative diseases of all types, broadly focusing on pathogenesis, treatment and prevention. Research on the normal structure and function of neural systems is also included to enable identification of intervention strategies.

Neurogenesis: Refers to the 'birth' of new neurons, while neuroplasticity refers to changes in brain structure in response to environmental stimuli. Neurogenesis is the process by which nervous system cells, also known as neurons, are produced by neural stem cells. The primary neural stem cell of the mammalian brain, called a radial glial cell, resides in an embryonic zone called the ventricular zone, which lies adjacent to the developing brain ventricles. An example of neuroplasticity would be synaptic plasticity, which refers to specifically to changes in the 'strength' of synapses, or the growth of new synapses.

Parkinson’s disease (PD):
the second most common neuro-degenerative disorder, results from loss of dopaminergic (DA) neurons in substantia nigra pars compacta, located in the mid-brain. It is a progressive disease marked by tremor, muscular rigidity, and slow, imprecise movement, chiefly affecting middle-aged and elderly people. It is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine.

SCI and MCI: (Subjective Cognitive Impairment and Mild Cognitive Impairment): SCI is worsening cognitive impairment that is noticeable to the individual, but in standard neurological testing, still falls in the normal range. At this early stage, PET scans and cerebrospinal fluid will often be abnormal and MRI may show some shrinkage of brain regions. SCI often lasts a decade or so before progressing to MCI. In the MCI stage neuro-psychological tests show that memory, organizing, speaking, calculating, planning or other cognitive abilities are abnormal, but the person is able to perform the "activities of daily living," such as dressing, eating, bathing. MCI does not inevitably progress to Alzheimer's Disease, but it is highly likely that Alzheimer's will follow in a few years.

Western Medicine:
A system in which medical doctors and other healthcare professionals (such as nurses, pharmacists, and therapists) treat symptoms and diseases using drugs, radiation, or surgery. Also called allopathic medicine, biomedicine, conventional medicine, mainstream medicine, and orthodox medicine.


About Dr. Dale E. Bredesen, MD Visit:

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*Dale E. Bredesen, MD. "The End of Alzheimer's." The first program to prevent and reverse cognitive decline. Copyright © 2017 Random House, LLC, New York, NY ISBN 9780735216204

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*Nutrigenomics is a branch of nutritional genomics and is the study of the effects of foods  and food constituents on gene expression. This means that nutrigenomics is research focusing on identifying and understanding molecular-level interaction between nutrients and other dietary bioactives with the genome. Nutrigenomics has also been described by the influence of genetic variation on nutrition by correlating gene expression or SNF's  with a nutrient's absorption, metabolism, elimination or biological effects. By doing so, nutrigenomics aims to develop rational means to optimise nutrition with respect to the subject's genotype.

By determining the mechanism of the effects of nutrients or the effects of a nutritional regime, nutrigenomics tries to define the causality|relationship between these specific nutrients and specific nutrient regimes (diets) on human health. Nutrigenomics has been associated with the idea of personalized nutrition based on genotype. While there is hope that nutrigenomics will ultimately enable such personalised dietary advice, it is a science still in its infancy and its contribution to public health over the next decade is thought to be major. While nutrigenomics is aimed at developing an understanding of how the whole body responds to a food via systems biology, research into the effect of a single gene/single food compound relationships is known as nutrigenetics.


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